Alcohol‐induced miR‐155 and HDAC11 inhibit negative regulators of the TLR4 pathway and lead to increased LPS responsiveness of Kupffer cells in alcoholic liver disease

Inflammation promotes the progression of alcoholic liver disease. Alcohol sensitizes KCs to gut‐derived endotoxin (LPS); however, signaling pathways that perpetuate inflammation in alcoholic liver disease are only partially understood. We found that chronic alcohol feeding in mice induced miR‐155, a...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Leukoc Biol
Autori principali: Bala, Shashi, Csak, Timea, Kodys, Karen, Catalano, Donna, Ambade, Aditya, Furi, Istvan, Lowe, Patrick, Cho, Yeonhee, Iracheta‐Vellve, Arvin, Szabo, Gyongyi
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
Soggetti:
Inflammation, Extracellular Mediators, & Effector Molecules
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608073/
https://ncbi.nlm.nih.gov/pubmed/28584078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.3A0716-310R
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi