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Alcohol‐induced miR‐155 and HDAC11 inhibit negative regulators of the TLR4 pathway and lead to increased LPS responsiveness of Kupffer cells in alcoholic liver disease
Inflammation promotes the progression of alcoholic liver disease. Alcohol sensitizes KCs to gut‐derived endotoxin (LPS); however, signaling pathways that perpetuate inflammation in alcoholic liver disease are only partially understood. We found that chronic alcohol feeding in mice induced miR‐155, a...
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| Publicado en: | J Leukoc Biol |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6608073/ https://ncbi.nlm.nih.gov/pubmed/28584078 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.3A0716-310R |
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