Alcohol‐induced miR‐155 and HDAC11 inhibit negative regulators of the TLR4 pathway and lead to increased LPS responsiveness of Kupffer cells in alcoholic liver disease

Inflammation promotes the progression of alcoholic liver disease. Alcohol sensitizes KCs to gut‐derived endotoxin (LPS); however, signaling pathways that perpetuate inflammation in alcoholic liver disease are only partially understood. We found that chronic alcohol feeding in mice induced miR‐155, a...

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Detalhes bibliográficos
Publicado no:J Leukoc Biol
Main Authors: Bala, Shashi, Csak, Timea, Kodys, Karen, Catalano, Donna, Ambade, Aditya, Furi, Istvan, Lowe, Patrick, Cho, Yeonhee, Iracheta‐Vellve, Arvin, Szabo, Gyongyi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Inflammation, Extracellular Mediators, & Effector Molecules
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608073/
https://ncbi.nlm.nih.gov/pubmed/28584078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.3A0716-310R
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