Dystrophin R16/17 protein therapy restores sarcolemmal nNOS in trans and improves muscle perfusion and function

BACKGROUND: Delocalization of neuronal nitric oxide synthase (nNOS) from the sarcolemma leads to functional muscle ischemia. This contributes to the pathogenesis in cachexia, aging and muscular dystrophy. Mutations in the gene encoding dystrophin result in Duchenne muscular dystrophy (DMD) and Becke...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Mol Med
Main Authors: Zhao, Junling, Yang, Hsiao Tung, Wasala, Lakmini, Zhang, Keqing, Yue, Yongping, Duan, Dongsheng, Lai, Yi
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6607532/
https://ncbi.nlm.nih.gov/pubmed/31266455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10020-019-0101-6
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker