Dystrophin R16/17 protein therapy restores sarcolemmal nNOS in trans and improves muscle perfusion and function

BACKGROUND: Delocalization of neuronal nitric oxide synthase (nNOS) from the sarcolemma leads to functional muscle ischemia. This contributes to the pathogenesis in cachexia, aging and muscular dystrophy. Mutations in the gene encoding dystrophin result in Duchenne muscular dystrophy (DMD) and Becke...

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Detaylı Bibliyografya
Yayımlandı:Mol Med
Asıl Yazarlar: Zhao, Junling, Yang, Hsiao Tung, Wasala, Lakmini, Zhang, Keqing, Yue, Yongping, Duan, Dongsheng, Lai, Yi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2019
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6607532/
https://ncbi.nlm.nih.gov/pubmed/31266455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10020-019-0101-6
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