Dystrophin R16/17 protein therapy restores sarcolemmal nNOS in trans and improves muscle perfusion and function

BACKGROUND: Delocalization of neuronal nitric oxide synthase (nNOS) from the sarcolemma leads to functional muscle ischemia. This contributes to the pathogenesis in cachexia, aging and muscular dystrophy. Mutations in the gene encoding dystrophin result in Duchenne muscular dystrophy (DMD) and Becke...

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Bibliografski detalji
Izdano u:Mol Med
Glavni autori: Zhao, Junling, Yang, Hsiao Tung, Wasala, Lakmini, Zhang, Keqing, Yue, Yongping, Duan, Dongsheng, Lai, Yi
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6607532/
https://ncbi.nlm.nih.gov/pubmed/31266455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10020-019-0101-6
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