Sarcolemmal nNOS anchoring reveals a qualitative difference between dystrophin and utrophin

Duchenne muscular dystrophy (DMD) is a lethal muscle disease caused by dystrophin deficiency. In normal muscle, dystrophin helps maintain sarcolemmal stability. Dystrophin also recruits neuronal nitric oxide synthase (nNOS) to the sarcolemma. Failure to anchor nNOS to the membrane leads to functiona...

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Bibliografiske detaljer
Main Authors: Li, Dejia, Bareja, Akshay, Judge, Luke, Yue, Yongping, Lai, Yi, Fairclough, Rebecca, Davies, Kay E., Chamberlain, Jeffrey S., Duan, Dongsheng
Format: Artigo
Sprog:Inglês
Udgivet: Company of Biologists 2010
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880012/
https://ncbi.nlm.nih.gov/pubmed/20483958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.064808
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