Sarcolemmal nNOS anchoring reveals a qualitative difference between dystrophin and utrophin

Duchenne muscular dystrophy (DMD) is a lethal muscle disease caused by dystrophin deficiency. In normal muscle, dystrophin helps maintain sarcolemmal stability. Dystrophin also recruits neuronal nitric oxide synthase (nNOS) to the sarcolemma. Failure to anchor nNOS to the membrane leads to functiona...

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Bibliografski detalji
Glavni autori: Li, Dejia, Bareja, Akshay, Judge, Luke, Yue, Yongping, Lai, Yi, Fairclough, Rebecca, Davies, Kay E., Chamberlain, Jeffrey S., Duan, Dongsheng
Format: Artigo
Jezik:Inglês
Izdano: Company of Biologists 2010
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880012/
https://ncbi.nlm.nih.gov/pubmed/20483958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.064808
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