Sarcolemmal nNOS anchoring reveals a qualitative difference between dystrophin and utrophin

Duchenne muscular dystrophy (DMD) is a lethal muscle disease caused by dystrophin deficiency. In normal muscle, dystrophin helps maintain sarcolemmal stability. Dystrophin also recruits neuronal nitric oxide synthase (nNOS) to the sarcolemma. Failure to anchor nNOS to the membrane leads to functiona...

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Dettagli Bibliografici
Autori principali: Li, Dejia, Bareja, Akshay, Judge, Luke, Yue, Yongping, Lai, Yi, Fairclough, Rebecca, Davies, Kay E., Chamberlain, Jeffrey S., Duan, Dongsheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: Company of Biologists 2010
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880012/
https://ncbi.nlm.nih.gov/pubmed/20483958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.064808
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