Sarcolemmal nNOS anchoring reveals a qualitative difference between dystrophin and utrophin

Duchenne muscular dystrophy (DMD) is a lethal muscle disease caused by dystrophin deficiency. In normal muscle, dystrophin helps maintain sarcolemmal stability. Dystrophin also recruits neuronal nitric oxide synthase (nNOS) to the sarcolemma. Failure to anchor nNOS to the membrane leads to functiona...

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Autors principals: Li, Dejia, Bareja, Akshay, Judge, Luke, Yue, Yongping, Lai, Yi, Fairclough, Rebecca, Davies, Kay E., Chamberlain, Jeffrey S., Duan, Dongsheng
Format: Artigo
Idioma:Inglês
Publicat: Company of Biologists 2010
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880012/
https://ncbi.nlm.nih.gov/pubmed/20483958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.064808
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