Dystrophins carrying spectrin-like repeats 16 and 17 anchor nNOS to the sarcolemma and enhance exercise performance in a mouse model of muscular dystrophy

Sarcolemma-associated neuronal NOS (nNOS) plays a critical role in normal muscle physiology. In Duchenne muscular dystrophy (DMD), the loss of sarcolemmal nNOS leads to functional ischemia and muscle damage; however, the mechanism of nNOS subcellular localization remains incompletely understood. Acc...

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Autores principales: Lai, Yi, Thomas, Gail D., Yue, Yongping, Yang, Hsiao T., Li, Dejia, Long, Chun, Judge, Luke, Bostick, Brian, Chamberlain, Jeffrey S., Terjung, Ronald L., Duan, Dongsheng
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2009
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648692/
https://ncbi.nlm.nih.gov/pubmed/19229108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36612
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