Microdystrophin Ameliorates Muscular Dystrophy in the Canine Model of Duchenne Muscular Dystrophy

Dystrophin deficiency results in lethal Duchenne muscular dystrophy (DMD). Substituting missing dystrophin with abbreviated microdystrophin has dramatically alleviated disease in mouse DMD models. Unfortunately, translation of microdystrophin therapy has been unsuccessful in dystrophic dogs, the onl...

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Autors principals: Shin, Jin-Hong, Pan, Xiufang, Hakim, Chady H, Yang, Hsiao T, Yue, Yongping, Zhang, Keqing, Terjung, Ronald L, Duan, Dongsheng
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616540/
https://ncbi.nlm.nih.gov/pubmed/23319056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.283
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