Microdystrophin Ameliorates Muscular Dystrophy in the Canine Model of Duchenne Muscular Dystrophy

Dystrophin deficiency results in lethal Duchenne muscular dystrophy (DMD). Substituting missing dystrophin with abbreviated microdystrophin has dramatically alleviated disease in mouse DMD models. Unfortunately, translation of microdystrophin therapy has been unsuccessful in dystrophic dogs, the onl...

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Hlavní autoři: Shin, Jin-Hong, Pan, Xiufang, Hakim, Chady H, Yang, Hsiao T, Yue, Yongping, Zhang, Keqing, Terjung, Ronald L, Duan, Dongsheng
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616540/
https://ncbi.nlm.nih.gov/pubmed/23319056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.283
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