Microdystrophin Ameliorates Muscular Dystrophy in the Canine Model of Duchenne Muscular Dystrophy

Dystrophin deficiency results in lethal Duchenne muscular dystrophy (DMD). Substituting missing dystrophin with abbreviated microdystrophin has dramatically alleviated disease in mouse DMD models. Unfortunately, translation of microdystrophin therapy has been unsuccessful in dystrophic dogs, the onl...

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Bibliografiske detaljer
Main Authors: Shin, Jin-Hong, Pan, Xiufang, Hakim, Chady H, Yang, Hsiao T, Yue, Yongping, Zhang, Keqing, Terjung, Ronald L, Duan, Dongsheng
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616540/
https://ncbi.nlm.nih.gov/pubmed/23319056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.283
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