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Partial restoration of cardiac function with ΔPDZ nNOS in aged mdx model of Duchenne cardiomyopathy

Transgenic gene deletion/over-expression studies have established the cardioprotective role of neuronal nitric oxide synthase (nNOS). However, it remains unclear whether nNOS-mediated heart protection can be translated to gene therapy. In this study, we generated an adeno-associated virus (AAV) nNOS...

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Hlavní autoři: Lai, Yi, Zhao, Junling, Yue, Yongping, Wasala, Nalinda B., Duan, Dongsheng
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4030774/
https://ncbi.nlm.nih.gov/pubmed/24463882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu029
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