Integrating Ligand-Receptor Interactions and In Vitro Evolution for Streamlined Discovery of Artificial Nucleic Acid Ligands

To discover DNA ligands against a predetermined receptor protein complex, we introduce a comprehensive version of ligand-guided selection (LIGS). LIGS is, itself, a variant of systematic evolution of ligands by exponential enrichment (SELEX). Herein, we have optimized LIGS to identify higher affinit...

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Bibliografiska uppgifter
I publikationen:Mol Ther Nucleic Acids
Huvudupphovsmän: Zumrut, Hasan E., Batool, Sana, Argyropoulos, Kimon V., Williams, Nicole, Azad, Roksana, Mallikaratchy, Prabodhika R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Gene & Cell Therapy 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606840/
https://ncbi.nlm.nih.gov/pubmed/31255977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.05.015
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