Dimerization of an aptamer generated from Ligand-guided Selection (LIGS) yields a high affinity scaffold against B-cells

Nucleic Acid Aptamers (NAAs) are a class of synthetic DNA or RNA molecules that bind specifically to their target. We recently introduced an aptamer termed R1.2 against membrane Immunoglobulin M (mIgM) expressing B-cell neoplasms using Ligand Guided Selection (LIGS). While LIGS-generated aptamers ar...

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Publicado en:Biochim Biophys Acta Gen Subj
Autores principales: Batool, Sana, Argyropoulos, Kimon V., Azad, Roksana, Okeoma, Precious, Zumrut, Hasan, Bhandari, Sanam, Dekhang, Rigzin, Mallikaratchy, Prabodhika R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6248343/
https://ncbi.nlm.nih.gov/pubmed/30342154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2018.10.006
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