Structural optimization of an aptamer generated from Ligand-Guided Selection (LIGS) resulted in high affinity variant toward mIgM expressed on Burkitt’s lymphoma cell lines

Aptamers are synthetic, short nucleic acid molecules capable of specific target recognition. Aptamers are selected using a screening method termed Systematic Evolution of ligands by Exponential enrichment (SELEX). We recently have introduced a variant of SELEX called “LIgand-Guided-Selection” (LIGS)...

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I publikationen:Biochim Biophys Acta
Huvudupphovsmän: Zümrüt, Hazan E., Batool, Sana, Van, Nabeela, George, Shanell, Bhandari, Sanam, Mallikaratchy, Prabodhika
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593314/
https://ncbi.nlm.nih.gov/pubmed/28363693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2017.03.020
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