Enhancer accessibility and CTCF occupancy underlie asymmetric TAD architecture and cell type specific genome topology

Cohesin and CTCF are master regulators of genome topology. How these ubiquitous proteins contribute to cell-type specific genome structure is poorly understood. Here, we explore quantitative aspects of topologically associated domains (TAD) between pluripotent embryonic stem cells (ESC) and lineage-...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Barrington, Christopher, Georgopoulou, Dimitra, Pezic, Dubravka, Varsally, Wazeer, Herrero, Javier, Hadjur, Suzana
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606583/
https://ncbi.nlm.nih.gov/pubmed/31266948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10725-9
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