Comparative Hi-C Reveals that CTCF Underlies Evolution of Chromosomal Domain Architecture

Topological domains are key architectural building blocks of chromosomes, but their functional importance and evolutionary dynamics are not well defined. We performed comparative high-throughput chromosome conformation capture (Hi-C) in four mammals and characterized the conservation and divergence...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Vietri Rudan, Matteo, Barrington, Christopher, Henderson, Stephen, Ernst, Christina, Odom, Duncan T., Tanay, Amos, Hadjur, Suzana
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4542312/
https://ncbi.nlm.nih.gov/pubmed/25732821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.02.004
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