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Enhancer accessibility and CTCF occupancy underlie asymmetric TAD architecture and cell type specific genome topology
Cohesin and CTCF are master regulators of genome topology. How these ubiquitous proteins contribute to cell-type specific genome structure is poorly understood. Here, we explore quantitative aspects of topologically associated domains (TAD) between pluripotent embryonic stem cells (ESC) and lineage-...
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| Veröffentlicht in: | Nat Commun |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6606583/ https://ncbi.nlm.nih.gov/pubmed/31266948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10725-9 |
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