GPCRomics: An approach to discover GPCR drug targets

G protein-coupled receptors (GPCRs) are targets for ~35% of approved drugs but only ~15% of the ~800 human GPCRs are currently such targets. GPCRomics, the use of unbiased, hypothesis-generating methods (e.g., RNA-sequencing [RNA-seq]), with tissues and cell types to identify and quantify GPCR expre...

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Udgivet i:Trends Pharmacol Sci
Main Authors: Insel, Paul A., Sriram, Krishna, Gorr, Matthew W., Wiley, Shu Z., Michkov, Alexander, Salmerón, Cristina, Chinn, Amy M.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6604616/
https://ncbi.nlm.nih.gov/pubmed/31078319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2019.04.001
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