Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer’s Disease Model

Cerebrovascular alterations are a key feature of Alzheimer’s disease (AD) pathogenesis. However, whether vascular damage contributes to synaptic dysfunction and how it synergizes with amyloid pathology to cause neuroinflammation and cognitive decline remain poorly understood. Here we show that the b...

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Publicado en:Neuron
Autores principales: Merlini, Mario, Rafalski, Victoria A., Coronado, Pamela Rios E., Gill, T. Michael, Ellisman, Maya, Muthukumar, Gayathri, Subramanian, Keshav S., Ryu, Jae Kyu, Syme, Catriona A., Davalos, Dimitrios, Seeley, William W., Mucke, Lennart, Nelson, Robert B., Akassoglou, Katerina
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6602536/
https://ncbi.nlm.nih.gov/pubmed/30737131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.01.014
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