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Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer’s Disease Model

Cerebrovascular alterations are a key feature of Alzheimer’s disease (AD) pathogenesis. However, whether vascular damage contributes to synaptic dysfunction and how it synergizes with amyloid pathology to cause neuroinflammation and cognitive decline remain poorly understood. Here we show that the b...

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Veröffentlicht in:Neuron
Hauptverfasser: Merlini, Mario, Rafalski, Victoria A., Coronado, Pamela Rios E., Gill, T. Michael, Ellisman, Maya, Muthukumar, Gayathri, Subramanian, Keshav S., Ryu, Jae Kyu, Syme, Catriona A., Davalos, Dimitrios, Seeley, William W., Mucke, Lennart, Nelson, Robert B., Akassoglou, Katerina
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6602536/
https://ncbi.nlm.nih.gov/pubmed/30737131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.01.014
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