Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer’s Disease Model

Cerebrovascular alterations are a key feature of Alzheimer’s disease (AD) pathogenesis. However, whether vascular damage contributes to synaptic dysfunction and how it synergizes with amyloid pathology to cause neuroinflammation and cognitive decline remain poorly understood. Here we show that the b...

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Publicado no:Neuron
Main Authors: Merlini, Mario, Rafalski, Victoria A., Coronado, Pamela Rios E., Gill, T. Michael, Ellisman, Maya, Muthukumar, Gayathri, Subramanian, Keshav S., Ryu, Jae Kyu, Syme, Catriona A., Davalos, Dimitrios, Seeley, William W., Mucke, Lennart, Nelson, Robert B., Akassoglou, Katerina
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6602536/
https://ncbi.nlm.nih.gov/pubmed/30737131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.01.014
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