Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy

Neuroinflammation is thought to contribute to the pathogenesis and maintenance of temporal lobe epilepsy, but the underlying cell and molecular mechanisms are not fully understood. The P2X7 receptor is an ionotropic receptor predominantly expressed on the surface of microglia, although neuronal expr...

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Опубликовано в: :J Neurosci
Главные авторы: Jimenez-Pacheco, Alba, Diaz-Hernandez, Miguel, Arribas-Blázquez, Marina, Sanz-Rodriguez, Amaya, Olivos-Oré, Luis A., Artalejo, Antonio R., Alves, Mariana, Letavic, Michael, Miras-Portugal, M. Teresa, Conroy, Ronan M., Delanty, Norman, Farrell, Michael A., O'Brien, Donncha F., Bhattacharya, Anindya, Engel, Tobias, Henshall, David C.
Формат: Artigo
Язык:Inglês
Опубликовано: Society for Neuroscience 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601816/
https://ncbi.nlm.nih.gov/pubmed/27251615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4009-15.2016
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