Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy

Neuroinflammation is thought to contribute to the pathogenesis and maintenance of temporal lobe epilepsy, but the underlying cell and molecular mechanisms are not fully understood. The P2X7 receptor is an ionotropic receptor predominantly expressed on the surface of microglia, although neuronal expr...

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Publicado no:J Neurosci
Main Authors: Jimenez-Pacheco, Alba, Diaz-Hernandez, Miguel, Arribas-Blázquez, Marina, Sanz-Rodriguez, Amaya, Olivos-Oré, Luis A., Artalejo, Antonio R., Alves, Mariana, Letavic, Michael, Miras-Portugal, M. Teresa, Conroy, Ronan M., Delanty, Norman, Farrell, Michael A., O'Brien, Donncha F., Bhattacharya, Anindya, Engel, Tobias, Henshall, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601816/
https://ncbi.nlm.nih.gov/pubmed/27251615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4009-15.2016
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