microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus

The ATP-gated ionotropic P2X7 receptor (P2X7R) modulates glial activation, cytokine production and neurotransmitter release following brain injury. Levels of the P2X7R are increased in experimental and human epilepsy but the mechanisms controlling P2X7R expression remain poorly understood. Here we i...

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Publicado no:Sci Rep
Main Authors: Jimenez-Mateos, Eva M., Arribas-Blazquez, Marina, Sanz-Rodriguez, Amaya, Concannon, Caoimhin, Olivos-Ore, Luis A., Reschke, Cristina R., Mooney, Claire M., Mooney, Catherine, Lugara, Eleonora, Morgan, James, Langa, Elena, Jimenez-Pacheco, Alba, Silva, Luiz Fernando Almeida, Mesuret, Guillaume, Boison, Detlev, Miras-Portugal, M. Teresa, Letavic, Michael, Artalejo, Antonio R., Bhattacharya, Anindya, Diaz-Hernandez, Miguel, Henshall, David C., Engel, Tobias
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4668358/
https://ncbi.nlm.nih.gov/pubmed/26631939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17486
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