Immune repertoire mining for rapid affinity optimization of mouse monoclonal antibodies

Traditional hybridoma and B cell cloning antibody discovery platforms have inherent limits in immune repertoire sampling depth. One consequence is that monoclonal antibody (mAb) leads often lack the necessary affinity for therapeutic applications, thus requiring labor-intensive and time-consuming af...

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Bibliografiske detaljer
Udgivet i:MAbs
Main Authors: Hsiao, Yi-Chun, Shang, Yonglei, DiCara, Danielle M., Yee, Angie, Lai, Joyce, Kim, Si Hyun, Ellerman, Diego, Corpuz, Racquel, Chen, Yongmei, Rajan, Sharmila, Cai, Hao, Wu, Yan, Seshasayee, Dhaya, Hötzel, Isidro
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2019
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601555/
https://ncbi.nlm.nih.gov/pubmed/30900945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1584517
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