Immune repertoire mining for rapid affinity optimization of mouse monoclonal antibodies

Traditional hybridoma and B cell cloning antibody discovery platforms have inherent limits in immune repertoire sampling depth. One consequence is that monoclonal antibody (mAb) leads often lack the necessary affinity for therapeutic applications, thus requiring labor-intensive and time-consuming af...

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Pubblicato in:MAbs
Autori principali: Hsiao, Yi-Chun, Shang, Yonglei, DiCara, Danielle M., Yee, Angie, Lai, Joyce, Kim, Si Hyun, Ellerman, Diego, Corpuz, Racquel, Chen, Yongmei, Rajan, Sharmila, Cai, Hao, Wu, Yan, Seshasayee, Dhaya, Hötzel, Isidro
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2019
Soggetti:
Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601555/
https://ncbi.nlm.nih.gov/pubmed/30900945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1584517
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