Immune repertoire mining for rapid affinity optimization of mouse monoclonal antibodies

Traditional hybridoma and B cell cloning antibody discovery platforms have inherent limits in immune repertoire sampling depth. One consequence is that monoclonal antibody (mAb) leads often lack the necessary affinity for therapeutic applications, thus requiring labor-intensive and time-consuming af...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Hsiao, Yi-Chun, Shang, Yonglei, DiCara, Danielle M., Yee, Angie, Lai, Joyce, Kim, Si Hyun, Ellerman, Diego, Corpuz, Racquel, Chen, Yongmei, Rajan, Sharmila, Cai, Hao, Wu, Yan, Seshasayee, Dhaya, Hötzel, Isidro
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601555/
https://ncbi.nlm.nih.gov/pubmed/30900945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1584517
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