Immune repertoire mining for rapid affinity optimization of mouse monoclonal antibodies

Traditional hybridoma and B cell cloning antibody discovery platforms have inherent limits in immune repertoire sampling depth. One consequence is that monoclonal antibody (mAb) leads often lack the necessary affinity for therapeutic applications, thus requiring labor-intensive and time-consuming af...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:MAbs
Päätekijät: Hsiao, Yi-Chun, Shang, Yonglei, DiCara, Danielle M., Yee, Angie, Lai, Joyce, Kim, Si Hyun, Ellerman, Diego, Corpuz, Racquel, Chen, Yongmei, Rajan, Sharmila, Cai, Hao, Wu, Yan, Seshasayee, Dhaya, Hötzel, Isidro
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Taylor & Francis 2019
Aiheet:
Report
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601555/
https://ncbi.nlm.nih.gov/pubmed/30900945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1584517
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