GADD45 promotes locus-specific DNA demethylation and 2C cycling in embryonic stem cells

Mouse embryonic stem cell (ESC) cultures contain a rare cell population of “2C-like” cells resembling two-cell embryos, the key stage of zygotic genome activation (ZGA). Little is known about positive regulators of the 2C-like state and two-cell stage embryos. Here we show that GADD45 (growth arrest...

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Détails bibliographiques
Publié dans:Genes Dev
Auteurs principaux: Schüle, Katrin M., Leichsenring, Manuel, Andreani, Tommaso, Vastolo, Viviana, Mallick, Medhavi, Musheev, Michael U., Karaulanov, Emil, Niehrs, Christof
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2019
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601511/
https://ncbi.nlm.nih.gov/pubmed/31171699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.325696.119
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