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GADD45A binds R-loops and recruits TET1 to CpG island promoters
R-loops are DNA:RNA hybrids enriched at CpG islands (CGIs), which can regulate chromatin states1–8. How R-loops are recognized and interpreted by specific epigenetic readers is unknown. Here we show that GADD45A (Growth Arrest and DNA Damage Protein 45A) directly binds to R-loops and mediates local...
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| Publicado no: | Nat Genet |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6420098/ https://ncbi.nlm.nih.gov/pubmed/30617255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0306-6 |
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