GADD45A binds R-loops and recruits TET1 to CpG island promoters

R-loops are DNA:RNA hybrids enriched at CpG islands (CGIs), which can regulate chromatin states1–8. How R-loops are recognized and interpreted by specific epigenetic readers is unknown. Here we show that GADD45A (Growth Arrest and DNA Damage Protein 45A) directly binds to R-loops and mediates local...

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Detaylı Bibliyografya
Yayımlandı:Nat Genet
Asıl Yazarlar: Arab, Khelifa, Karaulanov, Emil, Musheev, Michael, Trnka, Philipp, Schäfer, Andrea, Grummt, Ingrid, Niehrs, Christof
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420098/
https://ncbi.nlm.nih.gov/pubmed/30617255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0306-6
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