Persistence of the permeability transition pore in human mitochondria devoid of an assembled ATP synthase

The opening of the permeability transition pore, a nonspecific channel in inner mitochondrial membranes, is triggered by an elevated total concentration of calcium ions in the mitochondrial matrix, leading to disruption of the inner membrane and necrotic cell death. Cyclosporin A inhibits pore openi...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Carroll, Joe, He, Jiuya, Ding, Shujing, Fearnley, Ian M., Walker, John E.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2019
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601249/
https://ncbi.nlm.nih.gov/pubmed/31213546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904005116
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