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Persistence of the permeability transition pore in human mitochondria devoid of an assembled ATP synthase
The opening of the permeability transition pore, a nonspecific channel in inner mitochondrial membranes, is triggered by an elevated total concentration of calcium ions in the mitochondrial matrix, leading to disruption of the inner membrane and necrotic cell death. Cyclosporin A inhibits pore openi...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6601249/ https://ncbi.nlm.nih.gov/pubmed/31213546 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904005116 |
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