Persistence of the permeability transition pore in human mitochondria devoid of an assembled ATP synthase

The opening of the permeability transition pore, a nonspecific channel in inner mitochondrial membranes, is triggered by an elevated total concentration of calcium ions in the mitochondrial matrix, leading to disruption of the inner membrane and necrotic cell death. Cyclosporin A inhibits pore openi...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Carroll, Joe, He, Jiuya, Ding, Shujing, Fearnley, Ian M., Walker, John E.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601249/
https://ncbi.nlm.nih.gov/pubmed/31213546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904005116
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