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Permeability transition in human mitochondria persists in the absence of peripheral stalk subunits of ATP synthase
The opening of a nonspecific channel, known as the permeability transition pore (PTP), in the inner membranes of mitochondria can be triggered by calcium ions, leading to swelling of the organelle, disruption of the inner membrane and ATP synthesis, and cell death. Pore opening can be inhibited by c...
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| Опубликовано в: : | Proc Natl Acad Sci U S A |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5576841/ https://ncbi.nlm.nih.gov/pubmed/28784775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711201114 |
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