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Permeability transition in human mitochondria persists in the absence of peripheral stalk subunits of ATP synthase

The opening of a nonspecific channel, known as the permeability transition pore (PTP), in the inner membranes of mitochondria can be triggered by calcium ions, leading to swelling of the organelle, disruption of the inner membrane and ATP synthesis, and cell death. Pore opening can be inhibited by c...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: He, Jiuya, Carroll, Joe, Ding, Shujing, Fearnley, Ian M., Walker, John E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576841/
https://ncbi.nlm.nih.gov/pubmed/28784775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711201114
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