TGIF1 functions as a tumor suppressor in pancreatic ductal adenocarcinoma

A prominent function of TGIF1 is suppression of transforming growth factor beta (TGF‐β) signaling, whose inactivation is deemed instrumental to the progression of pancreatic ductal adenocarcinoma (PDAC), as exemplified by the frequent loss of the tumor suppressor gene SMAD4 in this malignancy. Surpr...

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Bibliographic Details
Published in:EMBO J
Main Authors: Parajuli, Parash, Singh, Purba, Wang, Zhe, Li, Lianna, Eragamreddi, Sailaja, Ozkan, Seval, Ferrigno, Olivier, Prunier, Celine, Razzaque, Mohammed S, Xu, Keli, Atfi, Azeddine
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601038/
https://ncbi.nlm.nih.gov/pubmed/31268604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018101067
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