TGIF Governs a Feed-Forward Network That Empowers Wnt Signaling to Drive Mammary Tumorigenesis

Many types of human cancers having hyperactivated Wnt signaling display no causative alterations in known effectors of this pathway. Here, we report a function of TGIF in Wnt signaling. TGIF associates with and diverts Axin1 and Axin2 from the β-Catenin destruction complex therefore allowing β-Caten...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Zhang, Ming-Zhu, Ferrigno, Olivier, Wang, Zhe, Ohnishi, Mutsuko, Prunier, Céline, Levy, Laurence, Razzaque, Mohammed, Horne, Williams C., Romero, Damian, Tzivion, Guri, Colland, Frédéric, Baron, Roland, Atfi, Azeddine
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398914/
https://ncbi.nlm.nih.gov/pubmed/25873176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.03.002
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