TGIF Governs a Feed-Forward Network That Empowers Wnt Signaling to Drive Mammary Tumorigenesis

Many types of human cancers having hyperactivated Wnt signaling display no causative alterations in known effectors of this pathway. Here, we report a function of TGIF in Wnt signaling. TGIF associates with and diverts Axin1 and Axin2 from the β-Catenin destruction complex therefore allowing β-Caten...

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Bibliografiset tiedot
Julkaisussa:Cancer Cell
Päätekijät: Zhang, Ming-Zhu, Ferrigno, Olivier, Wang, Zhe, Ohnishi, Mutsuko, Prunier, Céline, Levy, Laurence, Razzaque, Mohammed, Horne, Williams C., Romero, Damian, Tzivion, Guri, Colland, Frédéric, Baron, Roland, Atfi, Azeddine
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398914/
https://ncbi.nlm.nih.gov/pubmed/25873176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.03.002
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