TGIF Governs a Feed-Forward Network That Empowers Wnt Signaling to Drive Mammary Tumorigenesis

Many types of human cancers having hyperactivated Wnt signaling display no causative alterations in known effectors of this pathway. Here, we report a function of TGIF in Wnt signaling. TGIF associates with and diverts Axin1 and Axin2 from the β-Catenin destruction complex therefore allowing β-Caten...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Cancer Cell
Hlavní autoři: Zhang, Ming-Zhu, Ferrigno, Olivier, Wang, Zhe, Ohnishi, Mutsuko, Prunier, Céline, Levy, Laurence, Razzaque, Mohammed, Horne, Williams C., Romero, Damian, Tzivion, Guri, Colland, Frédéric, Baron, Roland, Atfi, Azeddine
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398914/
https://ncbi.nlm.nih.gov/pubmed/25873176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.03.002
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky