載入...
Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells
Tumor suppressor p53 is mutated in about 50% of cancers. Most malignant melanomas carry wild-type p53, but p53 activity is often inhibited due to overexpression of its negative regulators Mdm2 or MdmX. We performed high throughput screening of 2448 compounds on A375 cells carrying p53 activity lucif...
Na minha lista:
| 發表在: | Molecules |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
MDPI
2019
|
| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6600429/ https://ncbi.nlm.nih.gov/pubmed/31181622 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24112152 |
| 標簽: |
添加標簽
沒有標簽, 成為第一個標記此記錄!
|