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Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells

Tumor suppressor p53 is mutated in about 50% of cancers. Most malignant melanomas carry wild-type p53, but p53 activity is often inhibited due to overexpression of its negative regulators Mdm2 or MdmX. We performed high throughput screening of 2448 compounds on A375 cells carrying p53 activity lucif...

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Foilsithe in:Molecules
Main Authors: Mrkvová, Zuzana, Uldrijan, Stjepan, Pombinho, Antonio, Bartůněk, Petr, Slaninová, Iva
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6600429/
https://ncbi.nlm.nih.gov/pubmed/31181622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24112152
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