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A small molecule drug promoting miRNA processing induces alternative splicing of MdmX transcript and rescues p53 activity in human cancer cells overexpressing MdmX protein

MdmX overexpression contributes to the development of cancer by inhibiting tumor suppressor p53. A switch in the alternative splicing of MdmX transcript, leading to the inclusion of exon 6, has been identified as the primary mechanism responsible for increased MdmX protein levels in human cancers, i...

詳細記述

保存先:
書誌詳細
出版年:PLoS One
主要な著者: Valianatos, Georgios, Valcikova, Barbora, Growkova, Katerina, Verlande, Amandine, Mlcochova, Jitka, Radova, Lenka, Stetkova, Monika, Vyhnakova, Michaela, Slaby, Ondrej, Uldrijan, Stjepan
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626491/
https://ncbi.nlm.nih.gov/pubmed/28973015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0185801
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