A small molecule drug promoting miRNA processing induces alternative splicing of MdmX transcript and rescues p53 activity in human cancer cells overexpressing MdmX protein

MdmX overexpression contributes to the development of cancer by inhibiting tumor suppressor p53. A switch in the alternative splicing of MdmX transcript, leading to the inclusion of exon 6, has been identified as the primary mechanism responsible for increased MdmX protein levels in human cancers, i...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Valianatos, Georgios, Valcikova, Barbora, Growkova, Katerina, Verlande, Amandine, Mlcochova, Jitka, Radova, Lenka, Stetkova, Monika, Vyhnakova, Michaela, Slaby, Ondrej, Uldrijan, Stjepan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2017
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626491/
https://ncbi.nlm.nih.gov/pubmed/28973015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0185801
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