A small molecule drug promoting miRNA processing induces alternative splicing of MdmX transcript and rescues p53 activity in human cancer cells overexpressing MdmX protein

MdmX overexpression contributes to the development of cancer by inhibiting tumor suppressor p53. A switch in the alternative splicing of MdmX transcript, leading to the inclusion of exon 6, has been identified as the primary mechanism responsible for increased MdmX protein levels in human cancers, i...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Valianatos, Georgios, Valcikova, Barbora, Growkova, Katerina, Verlande, Amandine, Mlcochova, Jitka, Radova, Lenka, Stetkova, Monika, Vyhnakova, Michaela, Slaby, Ondrej, Uldrijan, Stjepan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626491/
https://ncbi.nlm.nih.gov/pubmed/28973015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0185801
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