Identification of a novel DGKα inhibitor for XLP-1 therapy by virtual screening

As part of an effort to identify druggable diacylglycerol kinase alpha (DGKα) inhibitors, we used an insilico approach based on chemical homology with the two commercially available DGKα inhibitors R59022 and R59949. Ritanserin and compound AMB639752 emerged from the screening of 127 compounds, show...

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Vydáno v:Eur J Med Chem
Hlavní autoři: Velnati, Suresh, Ruffo, Elisa, Massarotti, Alberto, Talmon, Maria, Varma, Konduru Sai Sandeep, Gesu, Alessandro, Fresu, Luigia Grazia, Snow, Andrew L., Bertoni, Alessandra, Capello, Daniela, Tron, Gian Cesare, Graziani, Andrea, Baldanzi, Gianluca
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599760/
https://ncbi.nlm.nih.gov/pubmed/30611057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.12.061
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