Structure activity relationship studies on Amb639752: toward the identification of a common pharmacophoric structure for DGKα inhibitors

A series of analogues of Amb639752, a novel diacylglycerol kinase (DGK) inhibitor recently discovered by us via virtual screening, have been tested. The compounds were evaluated as DGK inhibitors on α, θ, and ζ isoforms, and as antagonists on serotonin receptors. From these assays emerged two novel...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Velnati, Suresh, Massarotti, Alberto, Antona, Annamaria, Talmon, Maria, Fresu, Luigia Grazia, Galetto, Alessandra Silvia, Capello, Daniela, Bertoni, Alessandra, Mercalli, Valentina, Graziani, Andrea, Tron, Gian Cesare, Baldanzi, Gianluca
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6844378/
https://ncbi.nlm.nih.gov/pubmed/31690133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2019.1684911
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