Identification of a novel DGKα inhibitor for XLP-1 therapy by virtual screening

As part of an effort to identify druggable diacylglycerol kinase alpha (DGKα) inhibitors, we used an insilico approach based on chemical homology with the two commercially available DGKα inhibitors R59022 and R59949. Ritanserin and compound AMB639752 emerged from the screening of 127 compounds, show...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Velnati, Suresh, Ruffo, Elisa, Massarotti, Alberto, Talmon, Maria, Varma, Konduru Sai Sandeep, Gesu, Alessandro, Fresu, Luigia Grazia, Snow, Andrew L., Bertoni, Alessandra, Capello, Daniela, Tron, Gian Cesare, Graziani, Andrea, Baldanzi, Gianluca
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599760/
https://ncbi.nlm.nih.gov/pubmed/30611057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.12.061
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