Inhibition of diacylglycerol kinase alpha restores restimulation-induced cell death and reduces immunopathology in XLP-1

X-linked lymphoproliferative disease (XLP-1) is an often-fatal primary immunodeficiency associated with the exuberant expansion of activated CD8(+) T cells following Epstein-Barr virus (EBV) infection. XLP-1 is caused by defects in SAP, an adaptor protein that modulates T cell receptor (TCR)-induced...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Sci Transl Med
Päätekijät: Ruffo, Elisa, Malacarne, Valeria, Larsen, Sasha E., Das, Rupali, Patrussi, Laura, Wülfing, Christoph, Biskup, Christoph, Kapnick, Senta M., Verbist, Katherine, Tedrick, Paige, Schwartzberg, Pamela L., Baldari, Cosima T., Rubio, Ignacio, Nichols, Kim E., Snow, Andrew L., Baldanzi, Gianluca, Graziani, Andrea
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918505/
https://ncbi.nlm.nih.gov/pubmed/26764158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aad1565
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