Identification of a novel DGKα inhibitor for XLP-1 therapy by virtual screening

As part of an effort to identify druggable diacylglycerol kinase alpha (DGKα) inhibitors, we used an insilico approach based on chemical homology with the two commercially available DGKα inhibitors R59022 and R59949. Ritanserin and compound AMB639752 emerged from the screening of 127 compounds, show...

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Опубликовано в: :Eur J Med Chem
Главные авторы: Velnati, Suresh, Ruffo, Elisa, Massarotti, Alberto, Talmon, Maria, Varma, Konduru Sai Sandeep, Gesu, Alessandro, Fresu, Luigia Grazia, Snow, Andrew L., Bertoni, Alessandra, Capello, Daniela, Tron, Gian Cesare, Graziani, Andrea, Baldanzi, Gianluca
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599760/
https://ncbi.nlm.nih.gov/pubmed/30611057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.12.061
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