TET enzymes augment activation-induced deaminase (AID) expression via 5-hydroxymethylcytosine modifications at the Aicda superenhancer

TET enzymes are dioxygenases that promote DNA demethylation by oxidizing the methyl group of 5-methylcytosine to 5-hydroxymethylcytosine (5hmC). Here, we report a close correspondence between 5hmC-marked regions, chromatin accessibility and enhancer activity in B cells, and a strong enrichment for c...

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Gepubliceerd in:Sci Immunol
Hoofdauteurs: Lio, Chan-Wang J., Shukla, Vipul, Samaniego-Castruita, Daniela, González-Avalos, Edahi, Chakraborty, Abhijit, Yue, Xiaojing, Schatz, David G., Ay, Ferhat, Rao, Anjana
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599614/
https://ncbi.nlm.nih.gov/pubmed/31028100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aau7523
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