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Loss of TET2 and TET3 in regulatory T cells unleashes effector function
TET enzymes oxidize 5-methylcytosine to 5-hydroxymethylcytosine and other oxidized methylcytosines in DNA. Here we examine the role of TET proteins in regulatory T (Treg) cells. Tet2/3(fl/fl)Foxp3(Cre) mice lacking Tet2 and Tet3 in Treg cells develop inflammatory disease, and Treg cells from these m...
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| Pubblicato in: | Nat Commun |
|---|---|
| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6494907/ https://ncbi.nlm.nih.gov/pubmed/31043609 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09541-y |
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