Control of Foxp3 stability through modulation of TET activity

Ten-eleven translocation (TET) enzymes oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine and other oxidized methylcytosines, intermediates in DNA demethylation. In this study, we examine the role of TET proteins in regulating Foxp3, a transcription factor essential for the development and fu...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Yue, Xiaojing, Trifari, Sara, Äijö, Tarmo, Tsagaratou, Ageliki, Pastor, William A., Zepeda-Martínez, Jorge A., Lio, Chan-Wang J., Li, Xiang, Huang, Yun, Vijayanand, Pandurangan, Lähdesmäki, Harri, Rao, Anjana
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813667/
https://ncbi.nlm.nih.gov/pubmed/26903244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151438
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